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本实验室是中国科学院上海生科院生物化学与细胞生物学研究所细胞分化与凋亡课题组，是中国科学院分子细胞生物学重点实验室成员。本研究组承担及参与多项国家973计划重点研究项目以及国家自然科学基金委、科技部的重要科技项目。我们长期从事细胞增殖、凋亡和分化的信号传导机制研究。主要研究转化生长因子-beta在细胞增殖、凋亡和分化过程中的不同生物学效应及其相关的机制，包括其他因素或信号分子对转化生长因子-beta介导的生物学效应的调节作用。
现欲招收2-3名本科实习生，具体要求如下：
1.生物学及相关专业大三升大四本科生；
2.生活乐观、积极，具备良好的沟通和交流能力，对生物科学研究感兴趣，今后打算从事生物及相关行业。
3.做事勤奋、严谨，动手能力较强。
4.根据前三年的成绩已经取得（或者能够取得）免试读研资格（不要求特定推免读研单位），大四上学期或者整学年无课程安排及其他占用大量时间的事项，能够在本实验室至少实习半年以上，且每周能保持一定的实习工作时间（每周工作时间可以具体协商决定）。
本实验室具备细胞信号转导领域常用的各种实验手段（包括细胞、分子、生化、动物实验等方面的实验技术平台以及国际前沿的基因操作系统），在这里你可以学到各种前沿的实验技术，研究所齐全的共用仪器也将大大开阔你的眼界。本课题组将有专人负责带实习生，被招收的实习生将会发放一定数额的补助（基本满足食宿开支），并且将视具体参与课题研究的情况给予科研论文挂名、以及导师推荐信等待遇。并且如果需要，课题组将为实习生提供本科毕设论文的课题和实验条件。实习生被录用后可以根据本人情况从暑假或者下学期开始实习。
相信中科院的实习经历会带给你对未来更多的信心。
符合以上条件并有意申请者，请将本人简历（包括个人情况简介、毕业后去向以及感兴趣的方向等）e-mail至
yxw-th@yeah.net。我们将根据情况择优录取。
以下是本课题组近年来的代表性论文：
Wang D, Zhou Y, Lei W, Zhang K, Shi J, Hu Y, Shu G, Song J (2010). Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor γ (PPARγ). Biology of the Cell 102, 1-12.
Pan X, Wang X, Lei W, Min L, Yang Y, Wang X, Song J (2009). Nitric oxide suppresses transforming growth factor-β1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 50, 1577-87.
Zhang K, Tian H, Gao X, Lei W, Hu Y, Wang D, Pan X, Yu M, Xu G, Zhao F*, Song J* (2009). Ferritin Heavy Chain–Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition. Cancer Res 69, 5340-48.
Shi J, Wang D, Wang C, Hu Y, Liu A, Zhang Y, Sun B, Song J (2009). Insulin Receptor Substrate-1 Suppresses Transforming Growth Factor-{beta}1-Mediated Epithelial-Mesenchymal Transition. Cancer Res 69, 7180–7187.
Tian H, Zhang K, Gao X, Lei W, Zhang L, Yu M, Song J*, Zhao F*. Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta. Biochim Biophys Acta 1794, 1387-1397.
Zhang K, Wang D, Song J (2009). Cortactin is involved in transforming growth factor-β1-induced epithelial-mesenchymal transition in AML-12 cells. Acta Biochimica et Biophysica Sinica 41, 839–845.
Y Yang, X Pan, W Lei, J Wang and J Song. (2006) Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene. 25:7235-44
Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li and Jianguo Song. (2006) Regulation of Transforming Growth Factor-{beta}1-Induced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase A and Signal Transducers and Activators of Transcription 3. Cancer Res. 66:8617-24.
Yiran Zhou, Dongmei Wang, Fuqiang Li, Jian Shi and Jianguo Song. Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. Int J Biochem Cell Biol. 2006; 38:2151-63.
Bo Zhou, Fuqiang Li, Hehua Chen and Jianguo Song. The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. (2005) Int J Biochem Cell Biol. 37:1483-95.
Sheng Zhao, Yanan Yang and Jianguo Song (2004). Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. J. Cell. Physiol. 199:47-56.
Yanan Yang, Sheng Zhao, and Jianguo Song (2004). Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor-α1. Int. J. Biochem. Cell Biol. 36:223-34.
He-Hua Chen, Sheng Zhao and Jian-Guo Song (2003). TGF-α1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. Cell Death and Differentiation. 10:320-331.
Zhao S, Du X, Chen J, Zhou Y, Song J (2002). Secretory phospholipase A2 inhibits epidermal growth factor-induced receptor activation. Exp. Cell Res. 279:354-365.
Sheng Zhao, Xiao-Yan Du, Min-Qiang Chai, Jun-Song Chen, Yuan-Chong Zhou and Jian-Guo Song (2002).Secretory phospholipase A2 induces apoptosis via a mechanism involving ceramide generation. BBA-Mol Biol Cell Lipids. 1581:75-88.
Chai Min-Qiang, Chen Jun-Song, Zhao Sheng, Song Jian-Guo (2001). Propranolol increases phosphatidic acid level via phospholipase D activation. Acta Pharmacologica Sinica. 22 22:777-784.
Jinhui Liao, Junsong Chen, Minqiang Chai, Sheng Zhao, and Jianguo Song (2001). The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes. Cell Research, 11:89-94.
Junsong Chen and Jianguo Song (2001). Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. IUBMB Life, 51:49-56.
Binghong Zhou, Junsong Chen, Mingqiang Chai, Sheng Zhao, Jun Lian, Hehua Chen, and Jianguo Song (2000). Activation of phospholipase D activity in transforming growth factor-beta-induced cell growth inhibition. Cell Research, 10:139-149.
Jun-Song Chen, Min-Qiang Chai, He-Hua Chen, Sheng Zhao and Jian-Guo Song (2000). Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. BBA-Mol Biol Cell Lipids. 1488:219-232. |
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发表于 2010-6-30 20:21:27